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Synthesis and Antiviral Activity of 5-Substituted Cytidine Analogues: Identification of a Potent Inhibitor of Viral RNA-Dependent RNA Polymerases

As part of our studies of lethal viral mutagens, a series of 5-substituted cytidine analogues were synthesized and evaluated for antiviral activity. Among the compounds examined, 5-nitrocytidine was effective against poliovirus (PV) and coxsackievirus B3 (CVB3) and exhibited greater activity than th...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Harki, Daniel A., Graci, Jason D., Galarraga, Jessica E., Chain, William J., Cameron, Craig E., Peterson, Blake R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094219/
https://ncbi.nlm.nih.gov/pubmed/17034123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/JM060872x
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