Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

The thrombomodulin (TM) gene was ablated in mice in a cell type–restricted manner from vascular endothelium by Cre-recombinase–mediated excision controlled by the endothelial cell lineage–specific Tie2 promoter. Forty percent of mutant (TMLox-) mice display a distinct lethal embryonic phenotype not...

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Autori principali: Isermann, Berend, Hendrickson, Sara B., Zogg, Mark, Wing, Mark, Cummiskey, Marjorie, Kisanuki, Yaz Y., Yanagisawa, Masashi, Weiler, Hartmut
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC209404/
https://ncbi.nlm.nih.gov/pubmed/11518727
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