Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection

Fractalkine (Fk) is a structurally unusual member of the chemokine family. To determine its role in vivo, we generated mice with a targeted disruption of CX(3)CR1, the receptor for Fk. CX(3)CR1(–/–) mice were phenotypically indistinguishable from wild-type mice in a pathogen-free environment. In res...

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Pubblicato in:	J Clin Invest
Autori principali:	Haskell, Christopher A., Hancock, Wayne W., Salant, David J., Gao, Wei, Csizmadia, Vilmos, Peters, Wendy, Faia, Kerrie, Fituri, Omar, Rottman, James B., Charo, Israel F.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209384/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544273/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12976
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