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The Notch1 receptor is cleaved constitutively by a furin-like convertase

The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that proteolytic processing of p300 is an essential step in the formation of the biologically active receptor because only the c...

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Bibliografische gegevens
Hoofdauteurs: Logeat, Frédérique, Bessia, Christine, Brou, Christel, LeBail, Odile, Jarriault, Sophie, Seidah, Nabil G., Israël, Alain
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 1998
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20937/
https://ncbi.nlm.nih.gov/pubmed/9653148
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