Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles

Insulin stimulates glucose uptake by recruiting glucose transporter 4 (GLUT4) from an intracellular compartment to the cell surface; this phenomenon is defective in type 2 diabetes. Here we examine the involvement of actin filaments in GLUT4 translocation and their possible defects in insulin resist...

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Main Authors: Tong, Peter, Khayat, Zayna A., Huang, Carol, Patel, Nish, Ueyama, Atsunori, Klip, Amira
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC209359/
https://ncbi.nlm.nih.gov/pubmed/11489930
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