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Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

We have previously shown that the degradation of c-myc and N-myc in vitro is mediated by the ubiquitin system. However, the role of the system in targeting the myc proteins in vivo and the identity of the conjugating enzymes and possible ancillary proteins involved has remained obscure. Here we repo...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gross-Mesilaty, Shlomit, Reinstein, Eyal, Bercovich, Beatrice, Tobias, Karin E., Schwartz, Alan L., Kahana, Chaim, Ciechanover, Aaron
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20928/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9653139/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.14.8058
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