Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues

Lipoprotein lipase (LpL) binding to heparan sulfate proteoglycans (HSPGs) is hypothesized to stabilize the enzyme, localize LpL in specific capillary beds, and route lipoprotein lipids to the underlying tissues. To test these hypotheses in vivo, we created mice expressing a human LpL minigene (hLpL(...

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Bibliografiske detaljer
Main Authors: Lutz, E. Peer, Merkel, Martin, Kako, Yuko, Melford, Kristan, Radner, Herbert, Breslow, Jan L., Bensadoun, André, Goldberg, Ira J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209279/
https://ncbi.nlm.nih.gov/pubmed/11342582
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