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Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues

Lipoprotein lipase (LpL) binding to heparan sulfate proteoglycans (HSPGs) is hypothesized to stabilize the enzyme, localize LpL in specific capillary beds, and route lipoprotein lipids to the underlying tissues. To test these hypotheses in vivo, we created mice expressing a human LpL minigene (hLpL(...

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Main Authors: Lutz, E. Peer, Merkel, Martin, Kako, Yuko, Melford, Kristan, Radner, Herbert, Breslow, Jan L., Bensadoun, André, Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC209279/
https://ncbi.nlm.nih.gov/pubmed/11342582
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