Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis

Degradation of ECM, particularly interstitial collagen, promotes plaque instability, rendering atheroma prone to rupture. Previous studies implicated matrix metalloproteinases (MMPs) in these processes, suggesting that dysregulated MMP activity, probably due to imbalance with endogenous inhibitors,...

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Autores principales: Herman, Michael P., Sukhova, Galina K., Kisiel, Walter, Foster, Don, Kehry, Marilyn R., Libby, Peter, Schönbeck, Uwe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2001
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC209273/
https://ncbi.nlm.nih.gov/pubmed/11342575
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