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Absence of hisT-mediated tRNA pseudouridylation results in a uracil requirement that interferes with Escherichia coli K-12 cell division.

We show that hisT function is required for normal growth of Escherichia coli K-12, since a lack of hisT-mediated pseudouridine tRNA modification causes a uracil requirement that interferes with cell division. We also show that hisT transcription is positively growth rate regulated in exponentially g...

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Udgivet i:J Bacteriol
Principais autores: Tsui, H C, Arps, P J, Connolly, D M, Winkler, M E
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209251/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1938930/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.173.22.7395-7400.1991
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