Biochemical evidence for the existence of thymidylate synthase in the obligate intracellular parasite Chlamydia trachomatis.

Since eucaryotic cell-derived thymidine or thymidine nucleotides are not incorporated into Chlamydia trachomatis DNA, we hypothesized that C. trachomatis must obtain dTTP for DNA synthesis by converting dUMP to dTMP. In most cells, this reaction is catalyzed by thymidylate synthase (TS) and requires...

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Bibliographic Details

Published in:	J Bacteriol
Main Authors:	Fan, H Z, McClarty, G, Brunham, R C
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1991
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1938873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.173.21.6670-6677.1991
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