Biochemical evidence for the existence of thymidylate synthase in the obligate intracellular parasite Chlamydia trachomatis.

Since eucaryotic cell-derived thymidine or thymidine nucleotides are not incorporated into Chlamydia trachomatis DNA, we hypothesized that C. trachomatis must obtain dTTP for DNA synthesis by converting dUMP to dTMP. In most cells, this reaction is catalyzed by thymidylate synthase (TS) and requires...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Fan, H Z, McClarty, G, Brunham, R C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1938873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.173.21.6670-6677.1991
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