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Tumor necrosis factor α-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells

Ectodomain shedding of epidermal growth factor receptor (EGFR) ligands [e.g., transforming growth factor type α (TGF-α)] and EGFR phosphorylation are implicated in mucin production in airway epithelial cells. Tumor necrosis factor α-converting enzyme (TACE) is reported to cleave precursor of TGF-α,...

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Autors principals: Shao, Matt X. G., Ueki, Iris F., Nadel, Jay A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC208807/
https://ncbi.nlm.nih.gov/pubmed/12972643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1534804100
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