Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection

Both x-ray crystallography and chemical footprinting indicate that bases of the HIV type 1 (HIV-1) polypurine tract (PPT)-containing RNA/DNA hybrid deviate from standard Watson–Crick base pairing. However, the contribution of these structural anomalies to the accuracy of plus-strand primer selection...

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Détails bibliographiques
Auteurs principaux: Rausch, Jason W., Qu, Jin, Yi-Brunozzi, Hye Young, Kool, Eric T., Le Grice, Stuart F. J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2003
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC208748/
https://ncbi.nlm.nih.gov/pubmed/12972638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1932546100
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