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Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells

Inorganic polyphosphate (poly P), chains of hundreds of phosphate residues linked by “high-energy” bonds as in ATP, has been conserved from prebiotic times in all cells. Poly P is essential for a wide variety of functions in bacteria, including virulence in pathogens. In this study, we observe the u...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wang, Lihong, Fraley, Cresson D., Faridi, Jesika, Kornberg, Arthur, Roth, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208743/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12970465/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1534805100
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