Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

In the insulinoma cell line INS-1, a model system for glucose-regulated insulin secretion, the mitogen-activating protein (MAP) kinases/extracellular signal-regulated protein kinases, ERK1 and ERK2 are activated up to 15-fold by physiological concentrations of glucose, in the range of 3–12 mM. The r...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Khoo, Shih, Cobb, Melanie H.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1997
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20824/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5599
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