Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion
In the insulinoma cell line INS-1, a model system for glucose-regulated insulin secretion, the mitogen-activating protein (MAP) kinases/extracellular signal-regulated protein kinases, ERK1 and ERK2 are activated up to 15-fold by physiological concentrations of glucose, in the range of 3–12 mM. The r...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1997
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20824/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5599 |
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