The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy

The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a progressive toxic cardiomyopathy linked to mitochondrial damage and cardiomyocyte apoptosis. Here we demonstrate that the post-doxorubicin mouse heart fails to upregulate the nuclear program for mitochon...

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Autors principals: Suliman, Hagir B., Carraway, Martha Sue, Ali, Abdelwahid S., Reynolds, Chrystal M., Welty-Wolf, Karen E., Piantadosi, Claude A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2082137/
https://ncbi.nlm.nih.gov/pubmed/18037988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32967
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