A Switch in the Mechanism of Communication between the Two DNA-Binding Sites in the SfiI Restriction Endonuclease

While many Type II restriction enzymes are dimers with a single DNA-binding cleft between the subunits, SfiI is a tetramer of identical subunits. Two of its subunits (a dimeric unit) create one DNA-binding cleft, and the other two create a second cleft on the opposite side of the protein. The two cl...

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Bibliographic Details
Main Authors:	Bellamy, Stuart R.W., Milsom, Susan E., Kovacheva, Yana S., Sessions, Richard B., Halford, Stephen E.
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2082129/ https://ncbi.nlm.nih.gov/pubmed/17870087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.08.030
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A Switch in the Mechanism of Communication between the Two DNA-Binding Sites in the SfiI Restriction Endonuclease

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