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Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

Cyproterone acetate (CPA) is a steroidal antiandrogen used clinically in the treatment of prostate cancer. Compared with steroidal agonists for the androgen receptor (AR) (e.g. dihydrotestosterone, R1881), CPA is bulkier in structure and therefore seemingly incompatible with the binding pockets obse...

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Bibliografiske detaljer
Main Authors: Bohl, Casey E., Wu, Zengru, Miller, Duane D., Bell, Charles E., Dalton, James T.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080778/
https://ncbi.nlm.nih.gov/pubmed/17311914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M611711200
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