Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells

Interstrand cross-link (ICL) is a covalent modification of both strands of DNA, which prevents DNA strand separation during transcription and replication. Upon photoactivation 8-methoxypsoralen (8-MOP+UVA) alkylates both strands of DNA duplex at the 5,6-double bond of thymidines, generating monoaddu...

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Bibliographic Details
Main Authors: Couvé-Privat, Sophie, Macé, Gaëtane, Rosselli, Filippo, Saparbaev, Murat K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2078531/
https://ncbi.nlm.nih.gov/pubmed/17715144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm592
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