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Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells
Interstrand cross-link (ICL) is a covalent modification of both strands of DNA, which prevents DNA strand separation during transcription and replication. Upon photoactivation 8-methoxypsoralen (8-MOP+UVA) alkylates both strands of DNA duplex at the 5,6-double bond of thymidines, generating monoaddu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2078531/ https://ncbi.nlm.nih.gov/pubmed/17715144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm592 |
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