Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, at le...

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Main Authors: Young, Louise J., Wilson, Nicholas S., Schnorrer, Petra, Mount, Adele, Lundie, Rachel J., La Gruta, Nicole L., Crabb, Brendan S., Belz, Gabrielle T., Heath, William R., Villadangos, Jose A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077019/
https://ncbi.nlm.nih.gov/pubmed/17978177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708622104
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