Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice

To investigate the role of primary T cell repertoire selection in the immunopathogenesis of autoimmune diseases, pure thymic epithelium (TE) from nonobese diabetic (NOD) embryos was grafted into non autoimmune prone newborn C57BL/6 athymic mice. The results show that NOD TE selects host T cell reper...

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Hlavní autoři: Thomas-Vaslin, Véronique, Damotte, Diane, Coltey, Monique, Le Douarin, Nicole M., Coutinho, Antonio, Salaün, Josselyne
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC20769/
https://ncbi.nlm.nih.gov/pubmed/9114036
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