Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice

To investigate the role of primary T cell repertoire selection in the immunopathogenesis of autoimmune diseases, pure thymic epithelium (TE) from nonobese diabetic (NOD) embryos was grafted into non autoimmune prone newborn C57BL/6 athymic mice. The results show that NOD TE selects host T cell reper...

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Huvudupphovsmän: Thomas-Vaslin, Véronique, Damotte, Diane, Coltey, Monique, Le Douarin, Nicole M., Coutinho, Antonio, Salaün, Josselyne
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 1997
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC20769/
https://ncbi.nlm.nih.gov/pubmed/9114036
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