Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder

In the present study, we address the role of the gene for catechol-O-methyltransferase (COMT), a key modulator of dopaminergic and noradrenergic neurotransmission, in the genetic predisposition to obsessive-compulsive disorder (OCD). We show that a common functional allele of this gene, which result...

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Bibliographic Details
Main Authors: Karayiorgou, Maria, Altemus, Margaret, Galke, Brandi L., Goldman, David, Murphy, Dennis L., Ott, Jurg, Gogos, Joseph A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC20764/
https://ncbi.nlm.nih.gov/pubmed/9114031
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