Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells

The mitochondrial release of cytochrome c and Smac/DIABLO has been implicated in the activation of apoptosis in response to cell stress. Smac promotes cytochrome c-induced activation of caspases by sequestering the inhibitor of apoptosis protein (IAP) family of potent caspase suppressors. Differenti...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Pardo, Olivier E., Lesay, Adeline, Arcaro, Alexandre, Lopes, Rita, Ng, Bee Ling, Warne, Patricia H., McNeish, Iain A., Tetley, Teresa D., Lemoine, Nicholas R., Mehmet, Huseyin, Seckl, Michael J., Downward, Julian
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2003
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207633/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560006/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7600-7610.2003
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