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Critical Role of Ser-520 Phosphorylation for Membrane Recruitment and Activation of the ZAP-70 Tyrosine Kinase in T Cells

Regulation of protein tyrosine kinases (PTKs) by tyrosine phosphorylation is well recognized; in fact, nearly all PTKs require phosphorylation of tyrosine residues in their “activation loop” for catalytic activity. In contrast, the phosphorylation of PTKs on serine and threonine residues has not bee...

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Autors principals: Yang, Yaoming, Villain, Patricia, Mustelin, Tomas, Couture, Clément
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC207614/
https://ncbi.nlm.nih.gov/pubmed/14560012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7667-7677.2003
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