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Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA(2)α activity

The prevailing hypothesis that a signalling pathway involving cPLA(2)α is required to enhance the gating of the voltage-gated proton channel associated with NADPH oxidase was tested in human eosinophils and murine granulocytes. This hypothesis invokes arachidonic acid (AA) liberated by cPLA(2)α as a...

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Hlavní autoři: Morgan, Deri, Cherny, Vladimir V, Finnegan, Alison, Bollinger, James, Gelb, Michael H, DeCoursey, Thomas E
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075394/
https://ncbi.nlm.nih.gov/pubmed/17185330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.124248
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