Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy

Hypertrophic cardiomyocyte growth contributes substantially to the progression of heart failure. Activation of the plasma membrane Na(+)–H(+) exchanger (NHE1) and Cl(−)–HCO(3)(−) exchanger (AE3) has emerged as a central point in the hypertrophic cascade. Both NHE1 and AE3 bind carbonic anhydrase (CA...

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Main Authors: Alvarez, Bernardo V, Johnson, Danielle E, Sowah, Daniel, Soliman, Daniel, Light, Peter E, Xia, Ying, Karmazyn, Morris, Casey, Joseph R
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2007
Assuntos:
Cardiovascular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075384/
https://ncbi.nlm.nih.gov/pubmed/17124262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.123638
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