β-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice

Transepithelial sodium transport via alveolar epithelial Na(+) channels and Na(+),K(+)-ATPase constitutes the driving force for removal of alveolar oedema fluid. Decreased activity of the amiloride-sensitive epithelial Na(+) channel (ENaC) in the apical membrane of alveolar epithelial cells impairs...

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Hlavní autoři: Randrianarison, Nadia, Escoubet, Brigitte, Ferreira, Chrystophe, Fontayne, Alexandre, Fowler-Jaeger, Nicole, Clerici, Christine, Hummler, Edith, Rossier, Bernard C, Planès, Carole
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2007
Témata:
Respiratory
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075313/
https://ncbi.nlm.nih.gov/pubmed/17430990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.131078
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