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Potential Use of Toxic Thermolabile Proteins To Study Protein Quality Control Systems

SulA is an Escherichia coli division inhibitor with a short half-life whose accumulation results in filamentation. Here, we show that SulA is thermally unstable and forms aggregates at elevated temperatures. This property enables the selection of isolates with mutated protein quality control systems...

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Detalhes bibliográficos
Main Authors: Mizrahi, Itzhak, Dagan, Michael, Biran, Dvora, Ron, Eliora Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074907/
https://ncbi.nlm.nih.gov/pubmed/17644648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01067-07
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