Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma.

The monoclonal antibody (MAb) G250 binds to a tumour-associated antigen, expressed in renal cell carcinoma (RCC), which has been demonstrated to be a suitable target for antibody-mediated immunotherapy. A bispecific antibody having both G250 and anti-CD3 specificity can cross-link G250 antigen-expre...

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Main Authors: Luiten, R. M., Coney, L. R., Fleuren, G. J., Warnaar, S. O., Litvinov, S. V.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074712/
https://ncbi.nlm.nih.gov/pubmed/8795576
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