Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma.

The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We car...

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Autori principali: Eng, C., Foster, K. A., Healey, C. S., Houghton, C., Gayther, S. A., Mulligan, L. M., Ponder, B. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074627/
https://ncbi.nlm.nih.gov/pubmed/8695346
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