Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.

Inactivation of the p53 tumour-suppressor gene is common in a wide variety of human neoplasms. In the majority of cases, single point mutations in the protein-encoding sequence of p53 lead to positive immunohistochemistry (IHC) for the p53 protein, and are accompanied by loss of the wild-type allele...

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Autori principali: Slebos, R. J., Baas, I. O., Clement, M., Polak, M., Mulder, J. W., van den Berg, F. M., Hamilton, S. R., Offerhaus, G. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074586/
https://ncbi.nlm.nih.gov/pubmed/8688317
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