Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol.

Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in the tumour, but residual non-specific enzyme...

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Auteurs principaux: Eno-Amooquaye, E. A., Searle, F., Boden, J. A., Sharma, S. K., Burke, P. J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074478/
https://ncbi.nlm.nih.gov/pubmed/8645574
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