ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter.

The ToxR protein of Vibrio cholerae is an integral membrane protein that coordinately regulates the expression of virulence genes required for successful infection. ToxR has been shown to bind directly to and activate transcription of the cholera toxin (ctx) promoter. Within the amino-terminal cytop...

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Bibliographic Details
Main Authors: Ottemann, K M, DiRita, V J, Mekalanos, J J
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC207356/
https://ncbi.nlm.nih.gov/pubmed/1400230
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