Modulation of glucose responsiveness of insulinoma β-cells by graded overexpression of glucokinase
Insulinoma β-cells capable of overexpressing glucokinase under the control of a doxycycline-dependent transcriptional transactivator were established from parental INS-1 cells. Glucokinase could be maximally induced to a level more than 20 times the basal level after 36 h of culture with doxycycline...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20729/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9113996/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.9.4372 |
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