Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells

BACKGROUND: Polychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both. OBJECTIVE: Our objective was to identify individual PCBs that directly affect TH signaling by acting on the TR. ME...

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Autors principals: Gauger, Kelly J., Giera, Stefanie, Sharlin, David S., Bansal, Ruby, Iannacone, Eric, Zoeller, R. Thomas
Format: Artigo
Idioma:Inglês
Publicat: National Institute of Environmental Health Sciences 2007
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072832/
https://ncbi.nlm.nih.gov/pubmed/18007995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.10328
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