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Molecular Basis of the Apparent Near Ideality of Urea Solutions

Activity coefficients of urea solutions are calculated to explore the mechanism of its solution properties, which form the basis for its well-known use as a strong protein denaturant. We perform free energy simulations of urea solutions in different urea concentrations using two urea models (OPLS an...

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Detalhes bibliográficos
Main Authors: Kokubo, Hironori, Rösgen, Jörg, Bolen, D. Wayne, Pettitt, B. Montgomery
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072084/
https://ncbi.nlm.nih.gov/pubmed/17693466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.114181
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