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Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding
The keystone of the adaptive immune response is T cell receptor (TCR) recognition of peptide presented by Major Histocompatibility Complex (pMHC) molecules. The co-crystal structure of AHIII TCR bound to the MHC, HLA-A2, showed a large interface with an atypical binding orientation. MHC mutations in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2065754/ https://ncbi.nlm.nih.gov/pubmed/17825839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.028 |
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