KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1 binds to Rap1, a guanosine triphosphatase that mai...

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Bibliografische gegevens
Hoofdauteurs: Glading, Angela, Han, Jaewon, Stockton, Rebecca A., Ginsberg, Mark H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2007
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064761/
https://ncbi.nlm.nih.gov/pubmed/17954608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200705175
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