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KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions
Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1 binds to Rap1, a guanosine triphosphatase that mai...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064761/ https://ncbi.nlm.nih.gov/pubmed/17954608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200705175 |
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