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Defective Ca(2+) channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy
Proximal spinal muscular atrophy (SMA) is a motoneuron disease for which there is currently no effective treatment. In animal models of SMA, spinal motoneurons exhibit reduced axon elongation and growth cone size. These defects correlate with reduced β-actin messenger RNA and protein levels in dista...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064743/ https://ncbi.nlm.nih.gov/pubmed/17923533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200703187 |
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