Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize misfolded protein-induced cytotoxicity. However, the molecular mechanism by which misfolded proteins are recruited to aggresomes remains unclear. Mutations in the E3 ligase park...

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Detaylı Bibliyografya
Asıl Yazarlar: Olzmann, James A., Li, Lian, Chudaev, Maksim V., Chen, Jue, Perez, Francisco A., Palmiter, Richard D., Chin, Lih-Shen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2007
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064625/
https://ncbi.nlm.nih.gov/pubmed/17846173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200611128
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