The RGD motif in fibronectin is essential for development but dispensable for fibril assembly

Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three types of repeating modules: FN-I, FN-II, and FN-III. The interactions of α5β1 or αv integrins with the RGD motif of FN-III repeat 10 (FN-III(10)) are considered an essential step in the assembly of FN fibrils. T...

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Autori principali: Takahashi, Seiichiro, Leiss, Michael, Moser, Markus, Ohashi, Tomoo, Kitao, Tomoe, Heckmann, Dominik, Pfeifer, Alexander, Kessler, Horst, Takagi, Junichi, Erickson, Harold P., Fässler, Reinhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2007
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064432/
https://ncbi.nlm.nih.gov/pubmed/17591922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200703021
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