BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin

Bone morphogenic proteins (BMPs) are involved in axon pathfinding, but how they guide growth cones remains elusive. In this study, we report that a BMP7 gradient elicits bidirectional turning responses from nerve growth cones by acting through LIM kinase (LIMK) and Slingshot (SSH) phosphatase to reg...

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Bibliographic Details
Main Authors: Wen, Zhexing, Han, Liang, Bamburg, James R., Shim, Sangwoo, Ming, Guo-li, Zheng, James Q.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064427/
https://ncbi.nlm.nih.gov/pubmed/17606869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200703055
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