Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

Apicomplexan pathogens are obligate intracellular parasites. To enter cells, they must bind with high affinity to host cell receptors and then uncouple these interactions to complete invasion. Merozoites of Plasmodium falciparum, the parasite responsible for the most dangerous form of malaria, invad...

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Main Authors: O'Donnell, Rebecca A., Hackett, Fiona, Howell, Steven A., Treeck, Moritz, Struck, Nicole, Krnajski, Zita, Withers-Martinez, Chrislaine, Gilberger, Tim W., Blackman, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064393/
https://ncbi.nlm.nih.gov/pubmed/17000879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200604136
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