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Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1
Protease-activated receptor-1 (PAR1), a G protein–coupled receptor (GPCR) for thrombin, is irreversibly activated by proteolysis. Consequently, PAR1 trafficking is critical for the fidelity of thrombin signaling. PAR1 displays constitutive and agonist-induced internalization, which are clathrin and...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064289/ https://ncbi.nlm.nih.gov/pubmed/17535965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610154 |
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