Supervillin modulation of focal adhesions involving TRIP6/ZRP-1

Cell–substrate contacts, called focal adhesions (FAs), are dynamic in rapidly moving cells. We show that supervillin (SV)—a peripheral membrane protein that binds myosin II and F-actin in such cells—negatively regulates stress fibers, FAs, and cell–substrate adhesion. The major FA regulatory sequenc...

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Hlavní autoři: Takizawa, Norio, Smith, Tara C., Nebl, Thomas, Crowley, Jessica L., Palmieri, Stephen J., Lifshitz, Lawrence M., Ehrhardt, Anka G., Hoffman, Laura M., Beckerle, Mary C., Luna, Elizabeth J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2006
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064240/
https://ncbi.nlm.nih.gov/pubmed/16880273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200512051
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