To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

Chemoattractants like f-Met-Leu-Phe (fMLP) induce neutrophils to polarize by triggering divergent signals that promote the formation of protrusive filamentous actin (F-actin; frontness) and RhoA-dependent actomyosin contraction (backness). Frontness locally inhibits backness and vice versa. In neutr...

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Bibliografiske detaljer
Main Authors: Van Keymeulen, Alexandra, Wong, Kit, Knight, Zachary A., Govaerts, Cedric, Hahn, Klaus M., Shokat, Kevan M., Bourne, Henry R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064239/
https://ncbi.nlm.nih.gov/pubmed/16864657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200604113
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