Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase–mediated apoptosis of HeLa cells

We show that caspase-3 cleaves Cdc6 at D(290)/S and D(442)/G sites, producing p32-tCdc6 (truncated Cdc6) and p49-tCdc6, respectively, during etoposide- or tumor necrosis factor (TNF)-α–induced apoptosis. The expression of these tCdc6 proteins, p32- and p49-tCdc6, promotes etoposide-induced apoptosis...

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Bibliografiske detaljer
Main Authors: Yim, Hyungshin, Hwang, In Sun, Choi, Joon-Seok, Chun, Kwang-Hoon, Jin, Ying Hua, Ham, Young-Mi, Lee, Kwang Youl, Lee, Seung Ki
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064166/
https://ncbi.nlm.nih.gov/pubmed/16801388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200509141
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