Missing-in-metastasis and IRSp53 deform PI(4,5)P(2)-rich membranes by an inverse BAR domain–like mechanism

The actin cytoskeleton plays a fundamental role in various motile and morphogenetic processes involving membrane dynamics. We show that actin-binding proteins MIM (missing-in-metastasis) and IRSp53 directly bind PI(4,5)P(2)-rich membranes and deform them into tubular structures. This activity reside...

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Detalhes bibliográficos
Main Authors: Mattila, Pieta K., Pykäläinen, Anette, Saarikangas, Juha, Paavilainen, Ville O., Vihinen, Helena, Jokitalo, Eija, Lappalainen, Pekka
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064081/
https://ncbi.nlm.nih.gov/pubmed/17371834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609176
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